Anatomy and physiology
The main
blood vessel exiting the heart is called the aorta. The ascending aorta receives blood from the heart in the chest then curves
like a candy cane (aortic arch) down through the chest (descending thoracic aorta) and into the abdomen (abdominal aorta).
The aorta gives off branches to the head, chest, arms, abdomen, kidney, and legs. At the level of the belly button, the aorta
splits into two arteries. The left iliac artery and the right iliac artery carry blood down to the legs to the left and right
legs respectively.
Atherosclerosis is a disease that describes the formation
of plaque on blood vessels. Plaque which is composed of cholesterol, calcium, and fibrous tissue settles on the wall of the
artery. With the burden of this plaque, the wall of the aorta can weaken and balloon outward causing an aneurysm. An aneurysm
is similar in concept to a bubble on a tire or a bubble in a garden hose. The most common location of arterial aneurysm formation
is the abdominal aorta below the kidneys (infrarenal aorta). About half of infrarenal abdominal aortic aneurysms (AAA) involve
the iliac arteries. Aneurysm formation can occur in other portions of the aorta as well, including the portion of aorta above
the renal arteries (suprarenal aorta) and as high as the thoracic aorta.
An
aneurysm is a serious health problem because the weakened wall makes it prone to rupture once it reaches a certain size. Rupture
of an aneurysm is life-threatening as it causes massive bleeding. Occasionally, debris (emboli) contained within the aneurysm
can break off and travel to the legs or other organs blocking the blood flow to these tissues. If the blockage of blood flow
is prolonged, death of that tissue can occur.

Who is at Risk?
Risks of developing an aneurysm include age smoking, high cholesterol, high
blood pressure, and diabetes mellitus. Aneurysms are more common in individuals over the age of 60 years. Approximately 6-9%
of men over the age of 65 have an AAA. In addition, aortic aneurysms are four to five times more common in males than in females.
Lastly, aneurysms tend to run in families.
How is it diagnosed?
Most aneurysms, approximately three-quarters, are detected by chance. They may be seen on a CAT scan of the
abdomen performed for a completely different reason. They may also be detected on physical exam as an abnormal pulsation in
your abdomen. If your physician suspects that you may have an aneurysm, he or she will send you for an ultrasound to measure
the size of your abdominal aorta. If you are found to have an abdominal aortic aneurysm on ultrasound, the next step is to
get a CAT scan or MRI to get a better sense of the physical characteristics of the aneurysm.
The most
common symptom of an aneurysm is back pain. This is an ominous sign as it usually indicates a pending rupture or partial rupture.
How do I prepare for surgery?
Surgery is
recommended for aneurysms greater than 5cm (2 inches). For aneurysms less than 5cm, the risk of rupture is small such that
the risk of surgery outweigh the benefit of repair. The risks increases significantly when the aneurysm reaches 5cm and continues
to increase thereafter. Surgery is also recommended for aneurysms <5cm, if the aneurysm grows greater than 0.5cm in 6 months
or less.
Aortic surgery is a major operation. Your doctor will perform an extensive workup
to make sure that you can withstand the operation safely. Since atherosclerosis affects the entire arterial system, patients
with an abdominal aortic aneurysm often have other medical conditions such as heart disease, kidney disease, and are at high
risk for stroke. Many patients with aneurysms smoked at one point in their life and my have concomitant lung disease. The
tests your physicians may ask you have include a cardiac stress test to test your heart function under exercise. Lung function
tests particularly if you are or were a heavy smoker. Lastly blood work will be obtained to test the function of your kidneys.
If any noises (bruits) are heard in your neck during physical examination or if you ever had a stroke, an investigation of
your carotid (neck) arteries will be done usually with an ultrasound study. If you are found to have major heart disease or
carotid disease, you may be advised to have those conditions corrected before getting your aneurysm repaired.
You will be told not to eat or drink after midnight the night before surgery.
If you take any medications, ask your doctor
which ones you should take before surgery. Generally, it is advised that you take all your blood pressure medications the
morning before surgery with a very small sip of water.
How is the surgery performed?
Since aneurysm surgery involves making a long incision in your abdomen from
your breast bone to down below your belly button, your anesthesiologist may recommend an epidural catheter for pain control
after your operation. After the catheter has been placed, you will be put to sleep. A breathing tube will be inserted through
your mouth into your windpipe and a machine will breathe for you. A catheter that goes into your blood vessel will be inserted
into your neck to allow fluids and medications to be inserted directly into your vein. A catheter will also be placed into
your bladder to drain it during the operation and to keep a record of your urinary output.
Once all
the anesthesia preparations are performed, your surgeon will start your operation. An incision will be made from the base
of your breastbone to below your bellybutton. To reach the aorta which is located just above your spine, your bowels will
be moved to the side. Just like a plumber turns off the water valve before working on your pipes, a clamp will be placed onto
your aorta just above the aneurysm shutting off blood flow to the area. A second clamp will be placed just below the aneurysm.
The aneurysm will be opened, a graft will be sewn to normal aorta above and below where they aneurysm was. Once the aneurysm
is repaired, the clamps will be removed. The abdomen will be closed and you will be taken to the recovery room. Some blood
loss is expected and you may receive a blood transfusion during the surgery or afterwards.
An
alternative approach to aneurysm repair is via endovascular means. While proving to be a promising, minimally invasive method
to fix aneurysms, its long-term durability is not yet proven. Endovascular repair of AAA is achieved by making small 3 inch
incisions in your groin on both sides to reveal the common femoral artery. The stent graft device is introduced into the common
femoral artery and brought up into the aorta. The stent graft is seated just below the arteries to your kidneys into your
aorta and often extends to the common iliac artery on both sides. The incisions are then closed, usually with absorbable suture.
This approach avoids the large abdominal incision that must be made in the open approach. In addition, it is shorter and reduces
the required time under general anesthesia. In some cases, surgery is done under a local or regional anesthesia.

Complications of Surgery
As with every surgery, bleeding is always a risk. The risk of bleeding is higher with surgeries involving repair of
blood vessels. More than half of all patients undergoing aneurysm repair will need a blood transfusion. Bleeding after surgery
may require a second trip back to the operating room to wash out all the blood clots. Infection of the surgical wound is also
a potential risk. More often than not, this can be managed with antibiotics.
Open repair
The risks of surgery tend to relate to decrease blood flow to various tissue and organs of the body. Cardiovascular
complications such as heart attack and stroke while rare are the most common. Lung complications including need for supplemental
oxygen, dependence on a ventilator or breathing machine, and pneumonia are the second most common. Other serious complications
that happen less frequently include temporary kidney failure, rarely permanent renal failure requiring dialysis. This complication
tends to occur in patients who already have some degree of kidney disease. Decreased blood flow to the bowels leading to an
operation to remove dead bowel is another rare but serious complication. Paraplegia could also result from decreased blood
flow to the spinal cord.
Infection of the aortic graft is a complication that tends to occur many years after the operation. A serious and
potential deadly complication, it requires removal of the graft and performance of a bypass to restore blood flow to the legs.
Endovascular repair
The complications of endovascular repair
mimic some of the same complications seen with open repair but to a lesser extent. There are few other complications unique
to endovascular repair that are worth mentioning. Endovascular repair is still relatively new and its long term durability
has not yet been proven. Hence surveillance with regular, yearly abdominal cat scans are needed. The CT scans may reveal an
endoleak which is a persistent leak of blood around the aortic repair. A continual leak of blood prevents the aneurysm from
shrinking and the risk of rupture remains. Some types of endoleaks can be watched, others require a number of interventions
usually endovascular to seal the leak. Ultimately, if the leak can not be fixed endovascularly, an open operation may be necessary
to definitively fix the aneurysm. Other graft related problems can include kinking of the graft cutting off blood flow to
the legs or migration of the graft. An attempt to fix the problem via endovascular means is always made first. Finally, CT scans require use of a contrast agent to visualize the arteries. This contrast
can be toxic to the kidneys. In patients with a history of kidney disease, this could lead to worsening kidney function.
What to expect after surgery?
You will likely
stay in the ICU for 24-48 hours to monitor your blood pressure and obtain respiratory therapy. You can help to minimize complications
by coughing and doing breathing exercises. Since your bowels are moved
out of the way to identify the aorta, a tube will be inserted through your nose into the stomach. When the bowels are manipulated,
they become stunned and do not contract normally. If you eat too soon after surgery, you may vomit. Clear liquids and then eventually regular food will be started about two to three days after surgery. You will be
encouraged to get out of bed as early as day one to a chair followed by walking in the halls. Patients are generally discharged
from the hospital between five and ten days after an open repair and one to three days after an endovascular repair. Discharge
is mostly dependent upon being able to eat without being nauseas or vomiting, having a bowel movement, being off oxygen, and
being able to walk around enough to perform your activities of daily living.
At home, you should avoid lifting anything greater than a yellow pages phone book. Driving is not allowed while you are
on pain medication as the pain medication can make you confused and lightheaded. In general, before driving, you should simulate
driving maneuvers and making rapid turns in your car on your driveway before you take the road. There are no dietary restrictions,
although you should attend to a low fat, heart healthy diet. All efforts should be made to quit smoking. Your surgeon will
generally want to see you back anywhere from 2 to 4 weeks.